The offering of Veterinary Medicine traces it roots in 1992 when Veterinary Technology was first offered in Camarines Sur State Agricultural College (CSSAC) as a four-year course under the Department of Animal Science and Veterinary Technology (DASVT).

In May 7, 1999 the Board of Trustees per Resolution No. 323 signed by College President Dr. Magno S. Conag, Jr., approved the offering of Doctor of Veterinary Medicine. This was during the term of Dr. Julian Jose M. Trinidad as Chairperson of DASVT which was later named into Department of Animal and Veterinary Sciences (DAVS). In May 24 of the same year, the Commission on Higher Education approved the six-year DVM curriculum. 

The first DVM graduates in 2005 garnered 100% passing percentage.

In 2004 Veterinary Medicine was separated from DAVS and it became as the Department of Veterinary Medicine with Dr. Alberto M. Cabrera as the first Chairperson. It became an Institute in 2007 during the presidency of Atty. Marito T. Bernales. Then in 2011, two years after the creation of CSSAC into Central Bicol State University of Agriculture, it was named as the College of Veterinary Medicine.